COMPARATIVE ASSESSMENT OF BLOOD LEVELS OF HOMOCYSTEINE, HORMONES AND MINERALS IN CHILDREN WITH DIFFERENT LEVELS OF PHYSICAL GROWTH LIVING NEAR THE CHORNOBYL EXCLUSION ZONE
BANDAZHEVSKYI Yu.I., DUBOVA N.F.
Objective: We compared thecontent of homocysteine, hormones and minerals of the blood in the children with different levels of physical development living in the settlements near Chornobyl exclusion zone.
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BREAST CANCER PREVENTION IN DISTRICTS AFFECTED BY THE CHORNOBYL NUCLEAR POWER PLANT ACCIDENT BEGINNING FROM CHILD AGES
BANDAZHEVSKYI Yu.I., DUBOVA N.F.
The aim of this paper was to assess the prevalence of the T risk allele of the MTHFR:677 genetic polymorphism in a group of girls from Ivankivsky and Polіsky districts located near the Chornobyl exclusion zone. In addition, we assessed variants of combined carriership of the T allele with risk alleles of other genetic polymorphisms regulating the folate cycle.
HYPERHOMOCYSTEINEMIA AND CEREBROVASCULAR DISEASES IN PERSONS OF PRE‐ADVANCE AGE IN DISTRICTS AFFECTED BY THE ACCIDENT AT THE CHERNOBYL NUCLEAR POWER PLANT
BANDAZHEVSKYI Yu.I., DUBOVA N.F., USTINOVA L.A.
During the implementation of European Union projects in Ukraine «Health and environmental programs associated with the Chernobyl exclusion zone. Preparation, training and coordination of health projects» in 2015 hyperhomocysteinemia was observed in a group of adolescents living in districts bordering the Chernobyl exclusion zone in 75.3 % of cases (among males in 86.5 % of cases). An association between hyperhomocysteinemia and pathological processes in the central nervoussystem has been established. It is important to determine the causes of this phenomenon, including in pre‐conscription persons, which limits their suitability for military service.
The purpose of the study was to find out the reasons for the increase in homocysteine levels in male adolescents living in areas contaminated with radioactive elements as a result of the accident at the Chernobyl nuclear power plant.
FOREST FIRES IN THE CHERNOBYL EXCLUSION ZONE AND CHILDREN’S HEALTH
Bandazhevsky Yu. I., Dubovaya N. F.
Ivankov: PI Coordination and Analytical Center «Ecology and health», — Kyiv : «Aliant» LLC, 2021. 44 p.
ISBN 978-617-7819-10-2
The book is dedicated to the impact of forest fires in the Chernobyl Exclusion Zone on the health of children living in nearby localities. In addition, we have presented materials on levels of radioactive substances in the soil and forest trees of the Chernobyl Exclusion Zone and adjacent districts.
A blood level of homocysteine, a product of the essential amino acid methionine, was used as an integrative indicator that reflects the development of pathological processes in a child's body. The studies have shown an increase in the blood level of homocysteine in the group of adolescent children in 79.8% of cases after forest fires in the Chernobyl Exclusion Zone. The increase in cases of hyperhomocysteinemia in some subgroups of children, formed taking into account the genotypes of the folate cycle, was 10.8 - 35.3 % (in the total group - 22.6 %). The results of studies of changes in the level of homocysteine in the blood of the same children are consistent with the results of the comparative analysis of blood homocysteine levels in children from two districts before and after the fires in the Chernobyl Exclusion Zone.
THE ROLE OF FOLATE METABOLISM GENOME IN THE FORMATION OF TRIIODOTHYRONINE IN CHILDREN LIVING IN AREAS AFFECTED BY THE CHERNOBYL NUCLEAR POWER PLANT ACCIDENT
BANDAZHEVSKYI Yu.I., DUBOVA N.F.
Метою цього дослідження було визначення ролі геному фолатного циклу в утворенні трийодтироніну у дітей, які проживають на території, що постраждала від аварії на Чорнобильській атомній електростанції. Питома вага випадків підвищеного вмісту в крові трийодтироніну в групі дітей-носіїв алелі ризику G генетичного поліморфізму MTR:А2756G, пов’язаного з ферментом B12-залежна метіонін-синтаза, була достовірно більшою, ніж у групі дітей, які не мають цієї алелі – генотип A/A MTR:2756. Утворення трийодтироніну пов’язане з метаболічними перетвореннями гомоцистеїну за участю вітаміну В6 в якості кофактора ферменту цистатіонін-β-синтази. Причиною тиреотоксичних ефектів з ураженням серцево-судинної системи може бути високий рівень гомоцистеїну, пов’язаний з порушенням функціонування B12-залежної метіонін-синтази.
Защита здоровья людей в условиях радиационного загрязнения окружающей среды
Книга посвящена вопросам защиты здоровья людей, в условиях радиоактивного загрязнения среды обитания. Дана характеристика патологическим состояниям, вызванным инкорпорированным в организм Сs-137 – радионуклидом техногенного происхождения, наиболее распространенным в окружающей среде. Представлены основные направления защиты здоровья людей, длительное время проживающих на территории, пострадавшей от аварии на атомной электростанции.
Книга предназначена для медицинских работников, специалистов в области противорадиационной защиты, населения, проживающего на территории, пострадавшей от аварии на атомной электростанции.
ONCE AGAIN ABOUT VICTIMS OF THE CHERNOBYL DISASTER
Thirty-three years have passed since the accident at Reactor 4 at the Chernobyl nuclear power plant, yet the seriousness of this event for all humanity is still of concern. During the whole post-accident period, the nuclear lobby made many efforts to weaken public interest in this event. First of all, emphasis was made on the point that the tragedy had resulted in a small number of victims that included only workers of the nuclear power plant and firefighters involved in remedial actions to mitigate the consequences of the accident at the plant (31 people) and those who were permanently living in the most contaminated areas. It was concluded that the total number of Chernobyl victims who would die of cancer and leukaemia throughout their life would be less than 4000 people [1]. Some attention was also paid to migrants from reas with very high soil caesium-137 contamination levels.
