REGULATION OF THYROID FUNCTION IN CHILDREN LIVING IN AREAS AFFECTED BY THE CHORNOBYL NUCLEAR POWER PLANT ACCIDENT
Bandazhevsky Yu. I., Dubovaya N. F.
Ivankiv: PI Coordination and Analytical Center «Ecology and Health», — Kyiv, FOP Samchenko A. M., 2025. 80 р.
ISBN 978-617-8413-19-4
The book is devoted to the regulation of thyroid function in children living near the Chornobyl exclusion zone. A scientific concept is presented that reflects the regulatory relationships of sulfur-containing amino acids and thyroid hormones under conditions of radiation exposure. The book is intended for doctors of all specialties, ecologists, researchers, specialists in the field of radiation protection, and for anyone involved in the consequences of the accident at the Chornobyl nuclear power plant.
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PATHOLOGICAL AND ADAPTATION PROCESSES IN CHILDREN'S BODY AFTER THE ACCIDENT AT THE CHORNOBYL NUCLEAR POWER PLANT
Bandazhevsky Yu. I., Dubovaya N. F.
Ecology and Health Coordination and Analytical Centre, Ukraine (Kyiv 2026)
Our research over many decades allows us to draw a number of important conclusions regarding the radiation impact on the human population following the accident at the Chornobyl nuclear power plant (ChNPP).
The Chornobyl accident resulted in the release of a huge amount of radioactive elements into the environment, predominantly 137Cs. This radionuclide decays with the release of gamma and beta radiation, forming stable 137Ba.
137Cs entered and continues to enter the bodies of residents of the affected areas primarily through the enteral route with food of animal and plant origin.
In the USSR, as well as several independent states that emerged as a result of its dissolution, permissible levels of 137Cs and 90Sr in food products were established by law.
The rationale for creating these regulations was economic feasibility, based on the existence of agricultural products with certain levels of 137Cs and 90Sr in various years after the Chornobyl accident.
As the specific activity of these radionuclides in food products decreased, regulatory requirements were tightened.
However, this did not exclude the constant intake of radioactive elements into the human body.
CHERNOBYL CATASTROPHE AND CHILDREN’S HEALTH. 35 YEARS OF WORLD TRAGEDY
Bandazhevsky Yu. I., Dubovaya N. F.
Ivankov : PI Coordination and Analytical Center «Ecology and health», — Kyiv : «Alyant» LLC, 2022. 158 p.
ISBN 978-617-7819-29-4
The book is devoted to the long-term medical consequences of the Chernobyl disaster.
The results of scientific research projects of the European Union and France in 2013-2018 on the assessment of the health status of children living near the Chernobyl exclusion zone are presented.
This book was written for medical doctors of all specialties, ecologists, scientists, specialists in the field of radiation protection, and for anyone involved in the consequences of the accident at the Chernobyl nuclear power plant.
CS-137 RADIONUCLIDES, FOLATE CYCLE AND PHYSICAL DEVELOPMENT OF CHILDREN LIVING NEAR THE CHERNOBYL EXCLUSION ZONE
Bandazhevsky Yu. I., Dubovaya N. F.
The purpose of the study is to assess the impact of incorporated 137Cs radionuclides on the physical development of boys and girls living near the Chornobyl Exclusion Zone, taking into account the state of the folate cycle and the MTHFR:C677T genetic polymorphism.
COMPARATIVE ASSESSMENT OF BLOOD LEVELS OF HOMOCYSTEINE, HORMONES AND MINERALS IN CHILDREN WITH DIFFERENT LEVELS OF PHYSICAL GROWTH LIVING NEAR THE CHORNOBYL EXCLUSION ZONE
BANDAZHEVSKYI Yu.I., DUBOVA N.F.
Objective: We compared thecontent of homocysteine, hormones and minerals of the blood in the children with different levels of physical development living in the settlements near Chornobyl exclusion zone.
BREAST CANCER PREVENTION IN DISTRICTS AFFECTED BY THE CHORNOBYL NUCLEAR POWER PLANT ACCIDENT BEGINNING FROM CHILD AGES
BANDAZHEVSKYI Yu.I., DUBOVA N.F.
The aim of this paper was to assess the prevalence of the T risk allele of the MTHFR:677 genetic polymorphism in a group of girls from Ivankivsky and Polіsky districts located near the Chornobyl exclusion zone. In addition, we assessed variants of combined carriership of the T allele with risk alleles of other genetic polymorphisms regulating the folate cycle.
HYPERHOMOCYSTEINEMIA AND CEREBROVASCULAR DISEASES IN PERSONS OF PRE‐ADVANCE AGE IN DISTRICTS AFFECTED BY THE ACCIDENT AT THE CHERNOBYL NUCLEAR POWER PLANT
BANDAZHEVSKYI Yu.I., DUBOVA N.F., USTINOVA L.A.
During the implementation of European Union projects in Ukraine «Health and environmental programs associated with the Chernobyl exclusion zone. Preparation, training and coordination of health projects» in 2015 hyperhomocysteinemia was observed in a group of adolescents living in districts bordering the Chernobyl exclusion zone in 75.3 % of cases (among males in 86.5 % of cases). An association between hyperhomocysteinemia and pathological processes in the central nervoussystem has been established. It is important to determine the causes of this phenomenon, including in pre‐conscription persons, which limits their suitability for military service.
The purpose of the study was to find out the reasons for the increase in homocysteine levels in male adolescents living in areas contaminated with radioactive elements as a result of the accident at the Chernobyl nuclear power plant.
FOREST FIRES IN THE CHERNOBYL EXCLUSION ZONE AND CHILDREN’S HEALTH
Bandazhevsky Yu. I., Dubovaya N. F.
Ivankov: PI Coordination and Analytical Center «Ecology and health», — Kyiv : «Aliant» LLC, 2021. 44 p.
ISBN 978-617-7819-10-2
The book is dedicated to the impact of forest fires in the Chernobyl Exclusion Zone on the health of children living in nearby localities. In addition, we have presented materials on levels of radioactive substances in the soil and forest trees of the Chernobyl Exclusion Zone and adjacent districts.
A blood level of homocysteine, a product of the essential amino acid methionine, was used as an integrative indicator that reflects the development of pathological processes in a child's body. The studies have shown an increase in the blood level of homocysteine in the group of adolescent children in 79.8% of cases after forest fires in the Chernobyl Exclusion Zone. The increase in cases of hyperhomocysteinemia in some subgroups of children, formed taking into account the genotypes of the folate cycle, was 10.8 - 35.3 % (in the total group - 22.6 %). The results of studies of changes in the level of homocysteine in the blood of the same children are consistent with the results of the comparative analysis of blood homocysteine levels in children from two districts before and after the fires in the Chernobyl Exclusion Zone.
THE ROLE OF FOLATE METABOLISM GENOME IN THE FORMATION OF TRIIODOTHYRONINE IN CHILDREN LIVING IN AREAS AFFECTED BY THE CHERNOBYL NUCLEAR POWER PLANT ACCIDENT
BANDAZHEVSKYI Yu.I., DUBOVA N.F.
Метою цього дослідження було визначення ролі геному фолатного циклу в утворенні трийодтироніну у дітей, які проживають на території, що постраждала від аварії на Чорнобильській атомній електростанції. Питома вага випадків підвищеного вмісту в крові трийодтироніну в групі дітей-носіїв алелі ризику G генетичного поліморфізму MTR:А2756G, пов’язаного з ферментом B12-залежна метіонін-синтаза, була достовірно більшою, ніж у групі дітей, які не мають цієї алелі – генотип A/A MTR:2756. Утворення трийодтироніну пов’язане з метаболічними перетвореннями гомоцистеїну за участю вітаміну В6 в якості кофактора ферменту цистатіонін-β-синтази. Причиною тиреотоксичних ефектів з ураженням серцево-судинної системи може бути високий рівень гомоцистеїну, пов’язаний з порушенням функціонування B12-залежної метіонін-синтази.
